Sodium Glycerophosphate, with the CAS number 1555-56-2, is an organic sodium salt derived from glycerophosphoric acid. Known for its stability and solubility in water, this compound is commonly utilized across various industrial and laboratory applications.

Chemical Identity

Chemical Name: Sodium Glycerophosphate
CAS Number: 1555-56-2
Molecular Formula: C3H7Na2O6P
Molecular Weight: 216.03 g/mol
Synonyms: Disodium glycerophosphate, Glycerol-1-phosphate disodium salt

Physical and Chemical Properties

Appearance: White to off-white powder or crystalline solid
Solubility: Highly soluble in water
Stability: Stable under normal storage conditions
pH (1% solution): Slightly basic

These properties make sodium glycerophosphate ideal for formulations requiring water solubility and chemical stability.

Industrial and Technical Applications

1. Pharmaceutical Manufacturing

Sodium glycerophosphate is used as a buffering agent or stabilizer in various pharmaceutical preparations, particularly in injectable solutions. It is valued for its biocompatibility and ease of incorporation into liquid formulations.

2. Biochemical Research

In laboratory settings, sodium glycerophosphate functions as a phosphate source, buffering agent, or stabilizer in biochemical assays. It is often utilized in:
– Enzyme reactions
– Cell culture media
– Phosphorylation studies

3. Cosmetic and Personal Care Products

The compound is sometimes incorporated into skin-care and personal care formulations for its mild pH and ability to act as a humectant or buffering agent, helping maintain formulation stability and skin compatibility.

4. Nutraceutical and Supplement Manufacturing (Non-Edible Applications)

In non-food-grade formulations, sodium glycerophosphate is used for its solubility and reactivity in product prototypes that require a safe and bio-neutral phosphate source.

Handling and Safety

While sodium glycerophosphate is generally considered safe under controlled conditions, proper handling guidelines should always be followed:

Protective Equipment: Gloves, goggles, and appropriate lab attire
Storage Conditions: Store in a cool, dry place in tightly closed containers
Hazards: Avoid inhalation of dust; may cause mild irritation to eyes or skin
Disposal: Dispose in accordance with local, regional, and national regulations

Always consult the compound’s Material Safety Data Sheet (MSDS) for detailed safety and handling instructions.

Regulatory and Quality Standards

Sodium glycerophosphate is subject to quality standards and may be supplied in various grades depending on its intended use (e.g., industrial, laboratory, pharmaceutical-grade). Ensure you verify the specification and compliance data relevant to your specific application.

Conclusion

Sodium Glycerophosphate (CAS: 1555-56-2) is a versatile and stable compound widely used in pharmaceutical manufacturing, laboratory research, and technical applications. Its reliable buffering capacity, solubility, and safety profile make it a valuable component in many non-edible products and formulations. Always ensure appropriate grade selection and safety protocols when working with this chemical.

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